C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy
نویسندگان
چکیده
منابع مشابه
C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy
Volume 5 • Issue 5 • 1000212 J Nephrol Ther ISSN: 2161-0959 JNT, an open access journal C4d Glomerular Deposits and Disease Progression in Native Idiopathic Membranous Nephropathy Vincenzo Sepe1*, Paolo Albrizio2, and Antonio Dal Canton1,2 1Unit of Nephrology, Dialysis, Transplantation, Fondazione I.R.C.C.S., Policlinico San Matteo, Italy 2Chair of Nephrology, University of Pavia, Viale Camillo...
متن کاملGlomerular IgG subclasses in idiopathic and malignancy-associated membranous nephropathy
BACKGROUND In idiopathic membranous nephropathy (MN), antibodies directed towards the glomerular phospholipase A2 receptor (PLA2R) have mainly been reported to be of IgG4 subclass. However, the role of the different IgG subclasses in the pathogenesis of MN, both in idiopathic MN and in secondary cases, is still unclear. In this retrospective study, we test the hypothesis that the absence of glo...
متن کاملLow glomerular density is a risk factor for progression in idiopathic membranous nephropathy.
BACKGROUND The adverse histological features predicting a progressive loss of renal function in idiopathic membranous nephropathy (IMN), before the establishment of impaired renal function with advanced glomerulosclerosis and/or interstitial fibrosis, are still poorly understood. The present study examined the relationship between the glomerular density (GD; non-sclerotic glomerular number/rena...
متن کاملDistribution of glomerular IgG subclass deposits in patients with membranous nephropathy and anti-U1 ribonucleoprotein antibody.
BACKGROUND It is known that a predominant glomerular deposition of IgG4 is characteristic of idiopathic membranous nephropathy (MN) and that significant deposition of other IgG subclasses is also observed in lupus MN. However, there is no report focusing on the distribution of glomerular IgG subclass deposits in MN patients with anti-U1 ribonucleoprotein (RNP) antibody. METHODS We evaluated c...
متن کاملCombined Assessment of Phospholipase A2 Receptor Autoantibodies and Glomerular Deposits in Membranous Nephropathy.
Serum phospholipase A2 receptor antibodies (SAbs) and glomerular phospholipase A2 receptor antigen (GAg) deposits have been observed in idiopathic membranous nephropathy (IMN). However, the clinical application of these two biomarkers, particularly GAg deposition, needs to be further evaluated. We measured SAb concentration by ELISA and GAg deposition by immunofluorescence in 572 patients with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Nephrology & Therapeutics
سال: 2015
ISSN: 2161-0959
DOI: 10.4172/2161-0959.1000212